Studies Database

Leenaars M, Hooijmans C, de Vries R, Tillema A, Ritskes-Hoitinga M. New innovative elements in the FELASA Category C course for researchers: towards a more effective literature search and systematic reviews of animal studies. Paper presented at: The Three Rs - Together it's possible. 8th World Congress on Alternatives and Animal Use in the Life Sciences; 2011 Aug 21-25; Montreal, Canada

Thorough analysis of already existing literature and data is a prerequisite for executing well designed animal experiments. In this way, the maximum amount of information for animals (and humans) will be derived from previously performed studies, and unnecessary duplication is prevented. Systematic reviews are the most suitable way to carry out such a thorough analysis, since all relevant studies are identified, appraised, selected and data extracted to generate new data. Within clinical research, systematic reviews are common practice (evidence-based medicine). This is not yet the case within animal research. Because systematic reviews contribute to (1) better quality science, (2) implementation of the 3Rs and (3) better patient safety it is important to apply them. To introduce this evidence-based approach into animal research, we have implemented education on the basic principles of systematic reviews of animal studies into our FELASA category C courses over the last 2 years. Special attention is given to the development of comprehensive literature search strategies in a hands-on practical. We have also expanded the education on systematic reviews to a special dedicated 1 EC course for Master Biomedical Science students. The education is considered - both by teachers and students - to have an added value and to be a necessary part of education of future researchers. The content of the education, number of students and the evaluation reports will be discussed in the presentation. We suggest that these topics be included in all FELASA category C courses.

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