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Neuromuscular Pharmacology

Producer: Sheffield BioScience Programs

An interactive menu-driven program which simulates experiments performed on the sciatic nerve - anterior tibialis muscle preparation of the cat (in vivo) to illustrate the important differences in  the pharmacological action of depolarising (e.g. decamethonium) and non-depolarising (e.g.d-tubocurarine) blocking agents. High-resolution graphic simulations of experimental results (muscle contractions) are presented, in accelerated time, on a scrolling display to simulate a chart recorder. Phase I of each experiment compares the action of the two types of neuromuscular blocking agents: after either intravenous or close arterial administration; in conjunction with anticholinesterase or a different competitive (non-depolarising or depolarising) blocker; and in response to tetanic stimulation or to acetylcholine administered by close arterial injection. Phase II experiments compare the effects of 4 successive doses of decamethonium followed by the effects of tetanic stimulation and anticholinesterase. Information is included on the animal preparation, the method, and the clinical relevance of the different blocking agents. Each experiment has associated self-assessment questions with feedback.


Language Versions: English

Recommended System Requirements:

Microsoft Windows XP (32 bit), Windows Server 2003 (32-bit), Windows Server 2008 (32 bit), Windows Vista (32 bit), Windows 7 (32 bit and 64 bit), Windows 8
2.33GHz or faster x86-compatible processor, or Intel Atom 1.6GHz or faster processor for netbooks 128MB of RAM (1GB of RAM recommended for netbooks); 128MB of graphics memory Internet Explorer 7.0 or later, Mozilla Firefox 4.0 or later, Google Chrome, Safari 5.0 or later, or Opera 11.

Mac OS:
Mac OS X v10.6, v10.7, or v10.8
Intel Core Duo 1.83GHz or faster processor
256MB of RAM; 128MB of graphics memory
Safari 5.0 or later, Mozilla Firefox 4.0 or later, Google Chrome, or Opera 11

Target Audience: Undergraduate pharmacology, medical, bioscience and pharmacy students.

Price: £250 (multiuser, educational license)

Neuromuscular Pharmacology Neuromuscular Pharmacology Neuromuscular Pharmacology