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Langendorff Heart

Producer: Sheffield BioScience Programs

A highly interactive program that simulates experiments which may be performed on an isolated perfused mammalian heart (Langendorff preparation). In the Experiments section, simulated data, derived from actual data, is presented on a screen display which emulates a chart recorder. Students ‘design’ experiments by choosing, from a menu, a range of pharmacological agents which may be administered either alone, or in combination with an antagonist or a potentiator. Each trace represents several minutes of recording and thus allows students to access a large amount of data in a short period of time. A facility to compare traces of ‘drug X alone’ with ‘drug X + antagonist Y’ or ‘drug X + potentiator Z’ is available. This allows easy visual comparison of qualitative effects, and more accurate measurements can be taken from the screen. The program covers: 1. Effects of drugs given either alone or in combination with a range of antagonists or potentiators – sympathomimetics, parasympathomimetics, cardiac glycosides, coronary vasodilators, adenosine, histamine, verapamil; 2. Effect of ions – high and low concentrations of calcium, potassium and sodium; 3. Effect of increasing pre-load on contractile (ventricular) force (Starling’s law). The simulated responses (heart rate, ventricular force and coronary blood flow) are derived from actual experimental data and presented in high resolution colour graphics in a form comparable to that of a chart recorder. The program contains textual information describing the preparation and experimental method, and an editable on screen help facility allows teachers to tailor the information content of the program to specific groups of students.


Language Versions: English / Chinese / Serbian / Spanish

Recommended System Requirements:

Microsoft Windows XP (32 bit), Windows Server 2003 (32-bit), Windows Server 2008 (32 bit), Windows Vista (32 bit), Windows 7 (32 bit and 64 bit), Windows 8
2.33GHz or faster x86-compatible processor, or Intel Atom 1.6GHz or faster processor for netbooks 128MB of RAM (1GB of RAM recommended for netbooks); 128MB of graphics memory Internet Explorer 7.0 or later, Mozilla Firefox 4.0 or later, Google Chrome, Safari 5.0 or later, or Opera 11

Mac OS:
Mac OS X v10.6, v10.7, or v10.8
Intel Core Duo 1.83GHz or faster processor
256MB of RAM; 128MB of graphics memory
Safari 5.0 or later, Mozilla Firefox 4.0 or later, Google Chrome, or Opera 11

Target Audience: Undergraduate medical/pharmacology/pharmacy students.

Price: £250 (multiuser, educational license)

Screenshot of Langendorff Heart Screenshot of Langendorff Heart