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Inflammation Pharmacology

Producer: Sheffield BioScience Programs

This program simulates a range of experiments designed to demonstrate the action of inflammatory mediators and pharmacological agents on the in vivo inflammatory response in the anaesthetised rabbit, using data obtained from actual experiments. Introduction and Methods sections combine text and high-resolution graphics to describe the animal preparation, the methods employed to measure oedema formation and neutrophil accumulation, and to provide the student with the essential background information required to understand the inflammatory response.

The Experiments section allows the user to study the effects of the following agents on oedema formation (and where appropriate on neutrophil numbers) in normal rabbits:

1. A range of direct mediators of increased microvascular permeability, either alone (dose-response relationships), in the presence of a vasodilator (PGE2) or with receptor antagonists;

2. A range of agents which cause inflammation principally via neutrophil accumulation, either alone (dose-response relationships), or in the presence of a vasodilator (PGE2); the effects of neutrophil depletion and the importance of adhesion molecules are also covered;

3. Non-steroidal (local and systemic effects) and steroidal anti-inflammatory agents. A section describing the results of selected experiments using sensitised rabbits is also included and covers the IgG (Reverse Passive Arthus response) and IgE response. Results are presented in graphical form either as bar charts or line graphs.

Details:

Language Versions: English

Recommended System Requirements:

Windows:
Microsoft Windows XP (32 bit), Windows Server 2003 (32-bit), Windows Server 2008 (32 bit), Windows Vista (32 bit), Windows 7 (32 bit and 64 bit), Windows 8
2.33GHz or faster x86-compatible processor, or Intel Atom 1.6GHz or faster processor for netbooks
128MB of RAM (1GB of RAM recommended for netbooks); 128MB of graphics memory
Internet Explorer 7.0 or later, Mozilla Firefox 4.0 or later, Google Chrome, Safari 5.0 or later, or Opera 11

Mac OS:
Mac OS X v10.6, v10.7, or v10.8
Intel Core Duo 1.83GHz or faster processor
256MB of RAM; 128MB of graphics memory
Safari 5.0 or later, Mozilla Firefox 4.0 or later, Google Chrome, or Opera 11

Target Audience: Undergraduate pharmacology, pharmacy, biomedical science and medical students.

Price: £250 (multiuser, educational license)

Screenshot of Inflammation Pharmacology Screenshot of Inflammation Pharmacology