Rat Phrenic Nerve (In Vitro)

Producer: PIDATA

This program simulates the phrenic nerve - diaphragm preparation. The tissue can be exposed to drugs such as triethylcholine, 4-aminopyridine, succinylcholine, acetylcholine, carbachol, atropine, streptomycin, physostigmine, hexamethonium, tubocurarine, pancuronium, gallamine, fazadinium, decamethonium, choline, edrophonium, atracurium, dantrolene, lignocaine and neostigmine at any concentration and in any combination. The time sequence and order of addition is entirely in the hands of the user. Drug effects can be reversed by washing as required. Stimulation of the phrenic nerve can be turned off or applied at 0.05 Hz, 0.5 Hz or at 30 Hz for 5 secs. (tetanus). Output in the form of a simulated trace can be displayed on the screen or provided as a permanent record on a printer. Students can be asked to follow a schedule of drug administration fixed by the teacher and to observe and write-up effects produced in the normal way. Alternatively, students can design their own experiments to answer set questions or can learn about neuromuscular pharmacology using learn-by-discovery methods.


Year of production: 1995
Medium: 3.5" disk
System requirements: Windows only (all versions)
Price: £199.00 (multiuser, department licence for unlimited copies)